Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | GABRP | O00591 | 1/20 | 0.43 |
| ▸ | GABRD | O14764 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6089004 | 1.00 | ABL1 (0.45) | ABL1RETPDGFRBFGFR1FLT3 | |
| SCHEMBL6089999 | 0.89 | ALOX5 (0.47) | ABL1RETPDGFRBFGFR1FLT3 | |
| SCHEMBL6088720 | 0.89 | ABL1 (0.43) | ABL1RETPDGFRBFGFR1FLT3 | |
| SCHEMBL6089996 | 0.89 | ALOX5 (0.47) | ABL1RETPDGFRBFGFR1FLT3 | |
| SCHEMBL6088712 | 0.89 | ABL1 (0.43) | ABL1RETPDGFRBFGFR1FLT3 | |
| SCHEMBL6090981 | 0.83 | ALOX5 (0.46) | ABL1RETPDGFRBFGFR1FLT3 | |
| SCHEMBL6090979 | 0.83 | ALOX5 (0.46) | ABL1RETPDGFRBFGFR1FLT3 | |
| SCHEMBL6090402 | 0.83 | ABL1 (0.43) | ABL1RETPDGFRBFGFR1FLT3 | |
| SCHEMBL6090398 | 0.83 | ABL1 (0.43) | ABL1RETPDGFRBFGFR1FLT3 | |
| SCHEMBL6088797 | 0.82 | ABL1 (0.44) | ABL1RETPDGFRBFGFR1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |