Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 9/20 | 0.54 |
| ▸ | KDR | P35968 | 8/20 | 0.54 |
| ▸ | KIT | P10721 | 6/20 | 0.54 |
| ▸ | FLT4 | P35916 | 6/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.48 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.43 |
| ▸ | FLT1 | P17948 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6089073 | 1.00 | FLT3 (0.54) | FLT3KDRKITFLT4AURKB | |
| SCHEMBL6092121 | 0.87 | FLT3 (0.62) | FLT3KDRKITFLT4AURKB | |
| SCHEMBL6092116 | 0.87 | FLT3 (0.62) | FLT3KDRKITFLT4AURKB | |
| SCHEMBL6089642 | 0.79 | NTRK1 (0.45) | FLT3KDRAURKBPDGFRBPDGFRA | |
| SCHEMBL6089647 | 0.79 | NTRK1 (0.45) | FLT3KDRAURKBPDGFRBPDGFRA | |
| SCHEMBL6088501 | 0.78 | PDGFRB (0.46) | FLT3KDRKITFLT4AURKB | |
| SCHEMBL6088497 | 0.78 | PDGFRB (0.46) | FLT3KDRKITFLT4AURKB | |
| SCHEMBL6089527 | 0.78 | PDGFRB (0.45) | FLT3KDRKITFLT4AURKB | |
| SCHEMBL6087631 | 0.76 | PDGFRB (0.49) | FLT3KDRKITFLT4AURKB | |
| SCHEMBL6087629 | 0.76 | PDGFRB (0.49) | FLT3KDRKITFLT4AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | claimed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | claimed |
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | disclosed |