Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 10/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.62 |
| ▸ | KDR | P35968 | 5/20 | 0.56 |
| ▸ | FLT4 | P35916 | 5/20 | 0.56 |
| ▸ | KIT | P10721 | 4/20 | 0.56 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6092116 | 1.00 | FLT3 (0.62) | FLT3AURKBPDGFRBKDRFLT4 | |
| SCHEMBL6089073 | 0.87 | FLT3 (0.54) | FLT3AURKBPDGFRBKDRFLT4 | |
| SCHEMBL6089079 | 0.87 | FLT3 (0.54) | FLT3AURKBPDGFRBKDRFLT4 | |
| SCHEMBL6089903 | 0.80 | ALDH1A1 (0.48) | FLT3AURKBPDGFRBKDRPDGFRA | |
| SCHEMBL6090945 | 0.80 | TLK2 (0.49) | FLT3AURKBPDGFRBKDRFLT4 | |
| SCHEMBL6089091 | 0.80 | TLK2 (0.49) | FLT3AURKBPDGFRBKDRFLT4 | |
| SCHEMBL6089094 | 0.80 | TLK2 (0.49) | FLT3AURKBPDGFRBKDRFLT4 | |
| SCHEMBL6090940 | 0.80 | TLK2 (0.49) | FLT3AURKBPDGFRBKDRFLT4 | |
| SCHEMBL6091697 | 0.79 | TLK2 (0.48) | FLT3AURKBPDGFRBKDRFLT4 | |
| SCHEMBL6090785 | 0.78 | FLT3 (0.50) | FLT3AURKBPDGFRBKDRFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | claimed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | claimed |
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | disclosed |