Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 5/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 7/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 7/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 6/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6089154 | 1.00 | PDGFRB (0.45) | PDGFRBFGFR1ALKABL1RET | |
| SCHEMBL6090182 | 0.85 | KDR (0.56) | PDGFRBFGFR1ALKABL1RET | |
| SCHEMBL6090169 | 0.85 | KDR (0.56) | PDGFRBFGFR1ALKABL1RET | |
| SCHEMBL6093126 | 0.83 | PDGFRB (0.45) | PDGFRBFGFR1ALKABL1RET | |
| SCHEMBL6093136 | 0.83 | PDGFRB (0.45) | PDGFRBFGFR1ALKABL1RET | |
| SCHEMBL6090865 | 0.81 | PDGFRB (0.42) | PDGFRBFGFR1ALKABL1RET | |
| SCHEMBL6090880 | 0.81 | PDGFRB (0.42) | PDGFRBFGFR1ALKABL1RET | |
| SCHEMBL6089577 | 0.80 | KDR (0.44) | PDGFRBFGFR1ALKRETFLT3 | |
| SCHEMBL6089573 | 0.80 | KDR (0.44) | PDGFRBFGFR1ALKRETFLT3 | |
| SCHEMBL6089745 | 0.79 | KDR (0.59) | PDGFRBFGFR1ALKABL1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |