Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 4/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 7/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6093126 | 1.00 | PDGFRB (0.45) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL6089736 | 0.84 | KDR (0.55) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL6089730 | 0.84 | KDR (0.55) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL6089154 | 0.83 | PDGFRB (0.45) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL6089149 | 0.83 | PDGFRB (0.45) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL6089745 | 0.81 | KDR (0.59) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL6090880 | 0.81 | PDGFRB (0.42) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL6090865 | 0.81 | PDGFRB (0.42) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL6091254 | 0.80 | KDR (0.46) | PDGFRBFGFR1RETFLT3ALK | |
| SCHEMBL6091261 | 0.80 | KDR (0.46) | PDGFRBFGFR1RETFLT3ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |