Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 5/20 | 0.62 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.58 |
| ▸ | ALOX5AP | P20292 | 8/20 | 0.57 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.56 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | THPO | P40225 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6090654 | 0.93 | CYSLTR1 (0.63) | CYSLTR1ALOX5ALOX5APGPBAR1 | |
| SCHEMBL6088393 | 0.91 | CYSLTR1 (0.60) | CYSLTR1ALOX5GPBAR1CYSLTR2KDM4E | |
| SCHEMBL6088531 | 0.90 | CYSLTR1 (0.67) | CYSLTR1ALOX5ALOX5APGPBAR1CYSLTR2 | |
| SCHEMBL6087522 | 0.87 | CYSLTR1 (0.60) | CYSLTR1ALOX5ALOX5APGPBAR1CYSLTR2 | |
| SCHEMBL7005360 | 0.85 | CYSLTR1 (0.71) | CYSLTR1ALOX5GPBAR1CYSLTR2 | |
| SCHEMBL6088333 | 0.85 | CYSLTR1 (0.62) | CYSLTR1ALOX5ALOX5APGPBAR1CYSLTR2 | |
| SCHEMBL6090885 | 0.85 | CYSLTR1 (0.64) | CYSLTR1ALOX5GPBAR1CYSLTR2 | |
| SCHEMBL9818484 | 0.83 | CYSLTR1 (0.53) | CYSLTR1ALOX5ALOX5APGPBAR1 | |
| SCHEMBL10547803 | 0.82 | CYSLTR1 (0.69) | CYSLTR1ALOX5GPBAR1CYSLTR2 | |
| SCHEMBL9818410 | 0.82 | CYSLTR1 (0.52) | CYSLTR1ALOX5ALOX5APGPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |
| EP-1177176-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | Aventis Pharma Deutschland GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000064876-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-02 | — | — | WO | disclosed |