Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.53 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10421095 | 0.89 | CYSLTR1 (0.53) | CYSLTR1ALOX5APALOX5GPBAR1 | |
| SCHEMBL9818410 | 0.88 | CYSLTR1 (0.52) | CYSLTR1ALOX5APALOX5GPBAR1 | |
| SCHEMBL10532695 | 0.87 | CYSLTR1 (0.41) | CYSLTR1ALOX5APALOX5 | |
| SCHEMBL6088675 | 0.87 | CYSLTR1 (0.50) | CYSLTR1GPBAR1 | |
| SCHEMBL6090364 | 0.87 | CYSLTR1 (0.50) | CYSLTR1GPBAR1 | |
| SCHEMBL7010321 | 0.84 | CYSLTR1 (0.60) | CYSLTR1GPBAR1 | |
| SCHEMBL6089267 | 0.83 | CYSLTR1 (0.62) | CYSLTR1ALOX5APALOX5GPBAR1 | |
| SCHEMBL6089355 | 0.83 | CYSLTR1 (0.57) | CYSLTR1GPBAR1 | |
| SCHEMBL6088531 | 0.83 | CYSLTR1 (0.67) | CYSLTR1ALOX5APALOX5GPBAR1 | |
| SCHEMBL7008709 | 0.82 | CYSLTR1 (0.57) | CYSLTR1GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5059610-A | QUINOLINE DERIVATIVES AND THEIR USE AS ANTAGONISTS OF LEUKOTRIENE D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-10-22 | — | — | US | disclosed |
| US-4920132-A | Quinoline derivatives and use thereof as antagonists of leukotriene D4 | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |