Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | RECQL | P46063 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | TK1 | P04183 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6089323 | 1.00 | MAPT (0.32) | MAPTRECQLHTTKDRRAB9A | |
| SCHEMBL6090249 | 0.79 | KMT2A (0.42) | MAPTKDRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6090246 | 0.79 | KMT2A (0.42) | MAPTKDRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6089984 | 0.77 | MAPT (0.35) | MAPTRECQLHTTKDRRAB9A | |
| SCHEMBL6089981 | 0.77 | MAPT (0.35) | MAPTRECQLHTTKDRRAB9A | |
| SCHEMBL6088422 | 0.75 | KMT2A (0.44) | MAPTKDRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6088427 | 0.75 | KMT2A (0.44) | MAPTKDRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6088818 | 0.74 | KMT2A (0.42) | MAPTKDRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6088814 | 0.74 | KMT2A (0.42) | MAPTKDRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7493200 | 0.69 | KDM4E (0.35) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | claimed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | claimed |
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | disclosed |