Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.35 |
| ▸ | MEN1 | O00255 | 8/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.35 |
| ▸ | RECQL | P46063 | 7/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 4/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6089981 | 1.00 | MAPT (0.35) | MAPTMEN1KMT2ARECQLSMN1; SMN2 | |
| SCHEMBL6088988 | 0.81 | KDR (0.49) | MAPTMEN1KMT2ARECQLSMN1; SMN2 | |
| SCHEMBL6088995 | 0.81 | KDR (0.49) | MAPTMEN1KMT2ARECQLSMN1; SMN2 | |
| SCHEMBL6089202 | 0.79 | DHFR (0.43) | MAPTMEN1KMT2AKDRPOLB | |
| SCHEMBL6089206 | 0.79 | DHFR (0.43) | MAPTMEN1KMT2AKDRPOLB | |
| SCHEMBL6089319 | 0.77 | MAPT (0.32) | MAPTMEN1KMT2ARECQLSMN1; SMN2 | |
| SCHEMBL6089323 | 0.77 | MAPT (0.32) | MAPTMEN1KMT2ARECQLSMN1; SMN2 | |
| SCHEMBL7489008 | 0.70 | KDM4E (0.34) | MAPTMEN1KMT2ARAB9ALMNA | |
| SCHEMBL6088059 | 0.70 | ABCC2 (0.38) | MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL6088063 | 0.70 | ABCC2 (0.38) | MEN1KMT2ARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |