Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.67 |
| ▸ | KDR | P35968 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | CRHBP | P24387 | 1/20 | 0.55 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.54 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.52 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.52 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.52 |
| ▸ | INSR | P06213 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6089390 | 1.00 | MAPK14 (0.67) | MAPK14KDRKMT2AMEN1CRHBP | |
| SCHEMBL6088258 | 0.92 | MAPK14 (0.57) | MAPK14KDRKMT2AMEN1CRHBP | |
| SCHEMBL6089686 | 0.92 | MAPK14 (0.57) | MAPK14KDRKMT2AMEN1CRHBP | |
| SCHEMBL6090831 | 0.85 | MAPK14 (0.49) | MAPK14KDRKMT2AMEN1 | |
| SCHEMBL6088397 | 0.80 | KMT2A (0.64) | MAPK14KDRKMT2AMEN1CRHBP | |
| SCHEMBL6088402 | 0.80 | KMT2A (0.64) | MAPK14KDRKMT2AMEN1CRHBP | |
| SCHEMBL6091988 | 0.77 | KMT2A (0.60) | MAPK14KDRKMT2AMEN1CRHBP | |
| SCHEMBL6091982 | 0.77 | KMT2A (0.60) | MAPK14KDRKMT2AMEN1CRHBP | |
| SCHEMBL6090314 | 0.76 | KDR (0.59) | MAPK14KDRKMT2AMEN1CRHBP | |
| SCHEMBL6090317 | 0.76 | KDR (0.59) | MAPK14KDRKMT2AMEN1CRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |