Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.44 |
| ▸ | DHFR | P00374 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6092908 | 0.91 | SIRT1 (0.46) | MAPK14SIRT1SIRT5KMT2ADHFR | |
| SCHEMBL6092911 | 0.91 | SIRT1 (0.46) | MAPK14SIRT1SIRT5KMT2ADHFR | |
| SCHEMBL6089390 | 0.85 | MAPK14 (0.67) | MAPK14KMT2AMEN1KDR | |
| SCHEMBL6089394 | 0.85 | MAPK14 (0.67) | MAPK14KMT2AMEN1KDR | |
| SCHEMBL6090511 | 0.83 | KMT2A (0.48) | KMT2ADHFRMEN1POLBKDR | |
| SCHEMBL6090516 | 0.83 | KMT2A (0.48) | KMT2ADHFRMEN1POLBKDR | |
| SCHEMBL6090641 | 0.82 | MEN1 (0.45) | MAPK14KMT2AMEN1POLBKDR | |
| SCHEMBL6090637 | 0.82 | MEN1 (0.45) | MAPK14KMT2AMEN1POLBKDR | |
| SCHEMBL6090339 | 0.80 | KMT2A (0.45) | SIRT1SIRT5KMT2ADHFRMEN1 | |
| SCHEMBL6092288 | 0.80 | KMT2A (0.45) | KMT2ADHFRMEN1POLBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |