Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.43 |
| ▸ | CYSLTR1 | Q9Y271 | 6/20 | 0.43 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NQO1 | P15559 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6088343 | 0.91 | MAPT (0.41) | GPBAR1CYSLTR1MAPTNQO1 | |
| SCHEMBL6091137 | 0.89 | CYSLTR1 (0.45) | GPBAR1CYSLTR1CYSLTR2PDE10APDE4A | |
| SCHEMBL6087968 | 0.88 | CYSLTR1 (0.56) | GPBAR1CYSLTR1CYSLTR2PDE10A | |
| SCHEMBL6087715 | 0.85 | CYSLTR1 (0.40) | GPBAR1CYSLTR1CYSLTR2PDE10A | |
| SCHEMBL6089349 | 0.85 | CYSLTR1 (0.44) | GPBAR1CYSLTR1CYSLTR2 | |
| SCHEMBL6092367 | 0.84 | LMNA (0.48) | GPBAR1CYSLTR1CYSLTR2 | |
| SCHEMBL6089788 | 0.83 | CYSLTR1 (0.43) | GPBAR1CYSLTR1CYSLTR2 | |
| SCHEMBL6088340 | 0.83 | PFKFB3 (0.41) | TP53MAPTNQO1PDE10APDE4A | |
| SCHEMBL6088319 | 0.81 | MAPT (0.43) | GPBAR1CYSLTR1CYSLTR2TP53MAPT | |
| SCHEMBL6088875 | 0.80 | MAOB (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |
| CN-1183113-C | Tri-aryl acid derivatives as PPAR receptor ligands | ���ĵ�˹ҩ��¹�����˾ | 2005-01-05 | — | — | CN | disclosed |
| CN-1356983-A | Tri-aryl acid derivatives as PPAR receptor ligands | AVENTIS PHARM PROD INC (DE) | 2002-07-03 | — | — | CN | disclosed |
| EP-1177176-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | Aventis Pharma Deutschland GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000064876-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-02 | — | — | WO | disclosed |