Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 7/20 | 0.72 |
| ▸ | INSR | P06213 | 4/20 | 0.72 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.66 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.66 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.64 |
| ▸ | MYC | P01106 | 1/20 | 0.62 |
| ▸ | NAT1 | P18440 | 1/20 | 0.62 |
| ▸ | MAX | P61244 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | MITF | O75030 | 1/20 | 0.60 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.60 |
| ▸ | GSK3A | P49840 | 2/20 | 0.57 |
| ▸ | GSK3B | P49841 | 2/20 | 0.57 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | AHR | P35869 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3904134 | 1.00 | IGF1R (0.72) | IGF1RINSRHSPD1HSPE1SIRT2 | |
| SCHEMBL3904132 | 1.00 | IGF1R (0.72) | IGF1RINSRHSPD1HSPE1SIRT2 | |
| SCHEMBL14411129 | 0.88 | IGF1R (0.65) | IGF1RINSRHSPD1HSPE1MYC | |
| SCHEMBL5119790 | 0.88 | IGF1R (0.65) | IGF1RINSRHSPD1HSPE1MYC | |
| SCHEMBL5119787 | 0.88 | IGF1R (0.65) | IGF1RINSRHSPD1HSPE1MYC | |
| SCHEMBL6389114 | 0.87 | PIK3CG (0.79) | IGF1RINSRHSPD1HSPE1NAT1 | |
| SCHEMBL13388762 | 0.87 | IGF1R (0.72) | IGF1RINSRHSPD1HSPE1KMT2A | |
| SCHEMBL3897382 | 0.87 | IGF1R (0.79) | IGF1RINSRHSPD1HSPE1KMT2A | |
| SCHEMBL3904208 | 0.87 | IGF1R (0.79) | IGF1RINSRHSPD1HSPE1NAT1 | |
| SCHEMBL3897378 | 0.87 | IGF1R (0.79) | IGF1RINSRHSPD1HSPE1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060276520-A1 | Rhodanine derivatives and pharmaceutical compositions containing them | RIGEL PHARMACEUTICALS, INC. (US) | 2006-12-07 | — | — | US | disclosed |
| WO-2004043955-A1 | RHODANINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | RIGEL PHARMACEUTICALS, INC. (US) | 2004-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276520-A1 | Rhodanine derivatives and pharmaceutical compositions containing them | UBQLN1, UBQLN2, UBE2G2 | IGF1R 1698/4885INSR 2538/4885HSPD1 1909/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.