SCHEMBL6089770

SCHEMBL6089770

O=C1NN=C(c2ccccc2)/C1=C\c1cc2ccccc2[nH]1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR P35968 3/20 0.55
ALDH1A1 P00352 2/20 0.50
LMNA P02545 1/20 0.50
SIRT1 Q96EB6 1/20 0.49
CYP2A6 P11509 1/20 0.45
MAOB P27338 2/20 0.42
AMY1A P0DUB6 1/20 0.40
NPC1 O15118 2/20 0.40
RAB9A P51151 2/20 0.40
MAPT P10636 2/20 0.39
NPSR1 Q6W5P4 2/20 0.39
IDO1 P14902 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2D6 P10635 1/20 0.39
MAPK1 P28482 1/20 0.39
CYP2C19 P33261 1/20 0.39
PRF1 P14222 1/20 0.37
MAP4K1 Q92918 3/20 0.37
CDK5 Q00535 1/20 0.36
CDK5R1 Q15078 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6089777 1.00 KDR (0.55) KDRALDH1A1LMNASIRT1CYP2A6
SCHEMBL6092761 0.88 CYP19A1 (0.49) KDRALDH1A1LMNASIRT1CYP2A6
SCHEMBL6092766 0.88 CYP19A1 (0.49) KDRALDH1A1LMNASIRT1CYP2A6
SCHEMBL6088932 0.82 SIRT1 (0.45) KDRSIRT1CYP2A6MAOBAMY1A
SCHEMBL6090038 0.82 SIRT1 (0.47) KDRALDH1A1LMNASIRT1CYP2A6
SCHEMBL6090044 0.82 SIRT1 (0.47) KDRALDH1A1LMNASIRT1CYP2A6
SCHEMBL6088928 0.82 SIRT1 (0.45) KDRSIRT1CYP2A6MAOBAMY1A
SCHEMBL6088905 0.81 SIRT1 (0.44) KDRSIRT1CYP2A6MAOBAMY1A
SCHEMBL6088902 0.81 SIRT1 (0.44) KDRSIRT1CYP2A6MAOBAMY1A
SCHEMBL6089681 0.80 KDR (0.55) KDRSIRT1CYP2A6MAOBAMY1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1218373-A2 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 2002-07-03 EP claimed
WO-2001009121-A2 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 2001-02-08 WO claimed
US-7060822-B1 2-pyrazolin-5-ones ABBOTT GMBH & CO. KG (DE) 2006-06-13 US disclosed
EP-1218373-A2 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 2002-07-03 EP disclosed
WO-2001009121-A2 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 2001-02-08 WO disclosed