Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.31 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6089874 | 1.00 | KDR (0.58) | KDRCHEK1PDGFRBFGFR1ALK | |
| SCHEMBL6090337 | 0.86 | KDR (0.62) | KDRCHEK1ALKFLT3 | |
| SCHEMBL6090319 | 0.86 | KDR (0.62) | KDRCHEK1ALKFLT3 | |
| Hydrochloric Acid SCHEMBL6088830 | 0.86 | KDR (0.60) | KDRCHEK1PDGFRBFGFR1ALK | |
| Hydrochloric Acid SCHEMBL6088843 | 0.86 | KDR (0.60) | KDRCHEK1PDGFRBFGFR1ALK | |
| SCHEMBL6089179 | 0.85 | KDR (0.69) | KDRCHEK1PDGFRBFGFR1ALK | |
| SCHEMBL6089200 | 0.85 | KDR (0.69) | KDRCHEK1PDGFRBFGFR1ALK | |
| SCHEMBL6090600 | 0.84 | KDR (0.61) | KDRCHEK1PDGFRBFGFR1ALK | |
| SCHEMBL6090612 | 0.84 | KDR (0.61) | KDRCHEK1PDGFRBFGFR1ALK | |
| SCHEMBL6090089 | 0.84 | KDR (0.55) | KDRCHEK1PDGFRBFGFR1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | claimed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | claimed |
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | disclosed |