Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.61 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.61 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6090612 | 1.00 | KDR (0.61) | KDRCHEK1ABL1RETPDGFRB | |
| SCHEMBL6089745 | 0.89 | KDR (0.59) | KDRCHEK1ABL1RETPDGFRB | |
| SCHEMBL6090319 | 0.87 | KDR (0.62) | KDRCHEK1FLT3ALK | |
| SCHEMBL6090337 | 0.87 | KDR (0.62) | KDRCHEK1FLT3ALK | |
| SCHEMBL6089179 | 0.84 | KDR (0.69) | KDRCHEK1ABL1RETPDGFRB | |
| SCHEMBL6089200 | 0.84 | KDR (0.69) | KDRCHEK1ABL1RETPDGFRB | |
| SCHEMBL6089874 | 0.84 | KDR (0.58) | KDRCHEK1ABL1RETPDGFRB | |
| SCHEMBL6089385 | 0.84 | ALK (0.56) | KDRCHEK1ABL1RETPDGFRB | |
| SCHEMBL6089380 | 0.84 | ALK (0.56) | KDRCHEK1ABL1RETPDGFRB | |
| SCHEMBL6089886 | 0.84 | KDR (0.58) | KDRCHEK1ABL1RETPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |