Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.62 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | SYK | P43405 | 9/20 | 0.51 |
| ▸ | FCER2 | P06734 | 4/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.50 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.50 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6089894 | 1.00 | KDR (0.62) | KDRGSK3BSYKFCER2NTRK1 | |
| SCHEMBL6088407 | 0.83 | KMT2A (0.57) | KDRGSK3BSYKNTRK1NTRK3 | |
| SCHEMBL6088412 | 0.83 | KMT2A (0.57) | KDRGSK3BSYKNTRK1NTRK3 | |
| SCHEMBL6088475 | 0.80 | KDR (0.62) | KDRGSK3BSYKFCER2NTRK1 | |
| SCHEMBL6088468 | 0.80 | KDR (0.62) | KDRGSK3BSYKFCER2NTRK1 | |
| SCHEMBL6090500 | 0.77 | KDR (0.45) | KDRSYKFCER2NTRK1MEN1 | |
| SCHEMBL6090495 | 0.77 | KDR (0.45) | KDRSYKFCER2NTRK1MEN1 | |
| SCHEMBL7492063 | 0.74 | PIK3CA (0.44) | MEN1KMT2A | |
| SCHEMBL5464906 | 0.74 | SYK (0.72) | KDRGSK3BSYKFCER2NTRK1 | |
| SCHEMBL5464897 | 0.74 | SYK (0.72) | KDRGSK3BSYKFCER2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |