Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.45 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.42 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6088285 | 0.88 | KDR (0.46) | KDRPKN2PKN1PDGFRBFGFR1 | |
| SCHEMBL6088365 | 0.87 | KDR (0.47) | KDRPKN2PKN1PDGFRBFGFR1 | |
| SCHEMBL6088609 | 0.85 | KDR (0.61) | KDRPKN2PDGFRBFGFR1SRC | |
| SCHEMBL6088604 | 0.85 | KDR (0.61) | KDRPKN2PDGFRBFGFR1SRC | |
| SCHEMBL6090570 | 0.82 | KDR (0.43) | KDRPKN2PKN1PDGFRBFGFR1 | |
| SCHEMBL6090793 | 0.82 | KDR (0.46) | KDRPKN2PKN1PDGFRBFGFR1 | |
| SCHEMBL6089757 | 0.80 | KDR (0.42) | KDRPKN2PKN1PDGFRBFGFR1 | |
| SCHEMBL6089006 | 0.79 | KDR (0.41) | KDRPKN2PDGFRBFGFR1SRC | |
| SCHEMBL6089010 | 0.79 | KDR (0.41) | KDRPKN2PDGFRBFGFR1SRC | |
| SCHEMBL6091313 | 0.78 | KDR (0.50) | KDRPKN2PKN1PDGFRBFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |