Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.42 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.42 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.42 |
| ▸ | CDC7 | O00311 | 3/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.36 |
| ▸ | SRC | P12931 | 4/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 2/20 | 0.31 |
| ▸ | PLK4 | O00444 | 1/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.31 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.31 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6090570 | 0.82 | KDR (0.43) | KDRPKN1PKN2CDC7PDGFRB | |
| SCHEMBL6090793 | 0.82 | KDR (0.46) | KDRPKN1PKN2PDGFRBFGFR1 | |
| SCHEMBL6088365 | 0.81 | KDR (0.47) | KDRPKN1PKN2PDGFRBFGFR1 | |
| SCHEMBL6090633 | 0.80 | KDR (0.45) | KDRPKN1PKN2CDC7PDGFRB | |
| SCHEMBL6088285 | 0.79 | KDR (0.46) | KDRPKN1PKN2CDC7PDGFRB | |
| SCHEMBL6089729 | 0.78 | KDR (0.43) | KDRPKN1PKN2PDGFRBFGFR1 | |
| SCHEMBL6088171 | 0.78 | KDR (0.43) | KDRPKN1PKN2PDGFRBFGFR1 | |
| SCHEMBL6090489 | 0.78 | KDR (0.43) | KDRPKN1PKN2PDGFRBFGFR1 | |
| SCHEMBL6091313 | 0.76 | KDR (0.50) | KDRPKN1PKN2PDGFRBFGFR1 | |
| SCHEMBL6091305 | 0.76 | KDR (0.50) | KDRPKN1PKN2PDGFRBFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |