Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 3/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6090714 | 1.00 | KDR (0.42) | KDRALKALDH1A1LMNACHEK1 | |
| SCHEMBL6088322 | 0.88 | KDR (0.39) | KDRALKALDH1A1LMNACHEK1 | |
| SCHEMBL6088316 | 0.88 | KDR (0.39) | KDRALKALDH1A1LMNACHEK1 | |
| SCHEMBL6092147 | 0.88 | KDR (0.38) | KDRALDH1A1LMNACHEK1PIM1 | |
| SCHEMBL6092153 | 0.88 | KDR (0.38) | KDRALDH1A1LMNACHEK1PIM1 | |
| SCHEMBL6088730 | 0.83 | KDR (0.37) | KDRALDH1A1LMNACHEK1 | |
| SCHEMBL6088734 | 0.83 | KDR (0.37) | KDRALDH1A1LMNACHEK1 | |
| SCHEMBL6088104 | 0.83 | KDR (0.36) | KDRALDH1A1LMNACHEK1 | |
| SCHEMBL6088112 | 0.83 | KDR (0.36) | KDRALDH1A1LMNACHEK1 | |
| SCHEMBL6090271 | 0.83 | KDR (0.57) | KDRCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |