Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | THPO | P40225 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6090899 | 1.00 | KDM4E (0.40) | KDM4EALDH1A1GAASMN1; SMN2GLA | |
| SCHEMBL6091386 | 0.83 | KDM4E (0.40) | KDM4EALDH1A1GAASMN1; SMN2GLA | |
| SCHEMBL6092701 | 0.81 | PDE3B (0.37) | TSHRCYP3A4MAPK1HTTCHRNA7 | |
| SCHEMBL6092705 | 0.81 | PDE3B (0.37) | TSHRCYP3A4MAPK1HTTCHRNA7 | |
| SCHEMBL6091794 | 0.80 | ALDH1A1 (0.44) | KDM4EALDH1A1GAASMN1; SMN2HPGD | |
| SCHEMBL6091800 | 0.80 | ALDH1A1 (0.44) | KDM4EALDH1A1GAASMN1; SMN2HPGD | |
| SCHEMBL6089038 | 0.80 | ESR1 (0.36) | KDM4EALDH1A1GAASMN1; SMN2HPGD | |
| SCHEMBL6089041 | 0.80 | ESR1 (0.36) | KDM4EALDH1A1GAASMN1; SMN2HPGD | |
| SCHEMBL6090911 | 0.79 | MEN1 (0.40) | KDM4EALDH1A1GAASMN1; SMN2KMT2A | |
| SCHEMBL6090501 | 0.79 | BRD4 (0.36) | KDM4EALDH1A1GAAGLAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060004028-A1 | Novel PARP inhibitor | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004028-A1 | Novel PARP inhibitor | PARP1, PARP2, PARP11 | KDM4E 812/4885ALDH1A1 1890/4885GAA 2522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.