Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | TLK2 | Q86UE8 | 2/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6091251 | 1.00 | PDPK1 (0.40) | PDPK1LRRK2KDRTLK2SIRT2 | |
| SCHEMBL6088219 | 0.85 | LRRK2 (0.34) | LRRK2TLK2SIRT2 | |
| SCHEMBL6088217 | 0.85 | LRRK2 (0.34) | LRRK2TLK2SIRT2 | |
| SCHEMBL6090528 | 0.83 | PDPK1 (0.43) | PDPK1LRRK2TLK2SIRT2NPC1 | |
| SCHEMBL6090524 | 0.83 | PDPK1 (0.43) | PDPK1LRRK2TLK2SIRT2NPC1 | |
| SCHEMBL6090727 | 0.82 | LRRK2 (0.34) | LRRK2TLK2KMT2A | |
| SCHEMBL6091754 | 0.82 | ALDH1A1 (0.33) | LRRK2TLK2 | |
| SCHEMBL6091757 | 0.82 | ALDH1A1 (0.33) | LRRK2TLK2 | |
| SCHEMBL6091028 | 0.81 | KDR (0.40) | LRRK2KDRTLK2NPC1MAPT | |
| SCHEMBL6088887 | 0.81 | PDPK1 (0.40) | PDPK1KDRNPC1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | claimed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | claimed |
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | disclosed |