Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6089341 | 0.82 | KDR (0.46) | KDRCHEK1ALKPDGFRBFGFR1 | |
| SCHEMBL6090063 | 0.81 | KDR (0.45) | KDRCHEK1ALKPDGFRBFGFR1 | |
| SCHEMBL6092350 | 0.81 | KDR (0.41) | KDRCHEK1ALKPDGFRBFGFR1 | |
| SCHEMBL6090655 | 0.81 | KDR (0.46) | KDRCHEK1ALKALDH1A1HPGD | |
| SCHEMBL6090651 | 0.81 | KDR (0.46) | KDRCHEK1ALKALDH1A1HPGD | |
| SCHEMBL6089666 | 0.81 | KDR (0.51) | KDRCHEK1ALKALDH1A1HPGD | |
| SCHEMBL6089667 | 0.81 | KDR (0.51) | KDRCHEK1ALKALDH1A1HPGD | |
| SCHEMBL6090277 | 0.80 | KDR (0.47) | KDRCHEK1ALKALDH1A1LMNA | |
| SCHEMBL6092863 | 0.80 | KDR (0.44) | KDRCHEK1ALDH1A1LMNAPDGFRB | |
| SCHEMBL6089250 | 0.80 | KDR (0.45) | KDRCHEK1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |