Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.78 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6091354 | 1.00 | KDR (0.78) | KDRCHEK1ALDH1A1LMNAALK | |
| SCHEMBL6090243 | 0.93 | KDR (0.78) | KDRCHEK1ALDH1A1PDGFRBFGFR1 | |
| SCHEMBL6090206 | 0.93 | KDR (0.78) | KDRCHEK1ALDH1A1PDGFRBFGFR1 | |
| SCHEMBL6088270 | 0.92 | KDR (0.84) | KDRCHEK1PDGFRBFGFR1PRKAA2 | |
| SCHEMBL6088236 | 0.92 | KDR (0.84) | KDRCHEK1PDGFRBFGFR1PRKAA2 | |
| SCHEMBL6089147 | 0.91 | KDR (0.79) | KDRCHEK1PDGFRBFGFR1PRKAA2 | |
| SCHEMBL6089212 | 0.91 | KDR (0.79) | KDRCHEK1PDGFRBFGFR1PRKAA2 | |
| SCHEMBL6091598 | 0.90 | KDR (0.73) | KDRCHEK1PDGFRBFGFR1 | |
| SCHEMBL6091587 | 0.90 | KDR (0.73) | KDRCHEK1PDGFRBFGFR1 | |
| SCHEMBL7490353 | 0.88 | KDR (0.72) | KDRCHEK1PDGFRBFGFR1PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | claimed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | claimed |
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | disclosed |