Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.73 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.73 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.33 |
| ▸ | CDK1 | P06493 | 3/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.33 |
| ▸ | GSK3A | P49840 | 3/20 | 0.33 |
| ▸ | GSK3B | P49841 | 3/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.33 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6091598 | 1.00 | KDR (0.73) | KDRCHEK1PDGFRBFGFR1ALOX5 | |
| SCHEMBL6091354 | 0.90 | KDR (0.78) | KDRCHEK1PDGFRBFGFR1 | |
| SCHEMBL6091371 | 0.90 | KDR (0.78) | KDRCHEK1PDGFRBFGFR1 | |
| SCHEMBL6088270 | 0.89 | KDR (0.84) | KDRCHEK1PDGFRBFGFR1 | |
| SCHEMBL6088236 | 0.89 | KDR (0.84) | KDRCHEK1PDGFRBFGFR1 | |
| SCHEMBL6088770 | 0.89 | KDR (0.56) | KDRCHEK1PDGFRBFGFR1ALOX5 | |
| SCHEMBL6088735 | 0.89 | KDR (0.56) | KDRCHEK1PDGFRBFGFR1ALOX5 | |
| SCHEMBL6090893 | 0.87 | KDR (0.55) | KDRCHEK1PDGFRBFGFR1ALOX5 | |
| SCHEMBL6090855 | 0.87 | KDR (0.55) | KDRCHEK1PDGFRBFGFR1ALOX5 | |
| SCHEMBL6090243 | 0.87 | KDR (0.78) | KDRCHEK1PDGFRBFGFR1ZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |