Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ALPL | P05186 | 1/20 | 0.49 |
| ▸ | ALPI | P09923 | 1/20 | 0.49 |
| ▸ | ALPG | P10696 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 5/20 | 0.45 |
| ▸ | GALK1 | P51570 | 1/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 4/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | PRKACG | P22612 | 1/20 | 0.41 |
| ▸ | PRKACB | P22694 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6091752 | 1.00 | MEN1 (0.49) | MEN1KMT2AALPLALPIALPG | |
| SCHEMBL6089767 | 0.82 | RAF1 (0.45) | MEN1KMT2ARAF1SIRT1LCK | |
| SCHEMBL6089763 | 0.82 | RAF1 (0.45) | MEN1KMT2ARAF1SIRT1LCK | |
| SCHEMBL15178590 | 0.75 | PIM1 (0.39) | MEN1KMT2AIGF1RMAPK1PIM1 | |
| SCHEMBL6087575 | 0.74 | MAP4K1 (0.34) | KMT2AIGF1RPOLBMAPT | |
| SCHEMBL6087571 | 0.74 | MAP4K1 (0.34) | KMT2AIGF1RPOLBMAPT | |
| SCHEMBL19380311 | 0.73 | METAP1 (0.50) | MEN1KMT2AMAPK1KDM4EPIM1 | |
| SCHEMBL6089469 | 0.73 | RAF1 (0.49) | MEN1KMT2ARAF1SIRT1LCK | |
| SCHEMBL6089459 | 0.73 | RAF1 (0.49) | MEN1KMT2ARAF1SIRT1LCK | |
| SCHEMBL990866 | 0.72 | MEN1 (0.53) | MEN1KMT2ASIRT1MAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |