Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 5/20 | 0.45 |
| ▸ | LCK | P06239 | 5/20 | 0.45 |
| ▸ | PRKACA | P17612 | 2/20 | 0.43 |
| ▸ | PRKACG | P22612 | 2/20 | 0.43 |
| ▸ | PRKACB | P22694 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | MAP1LC3B | Q9GZQ8 | 3/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6089767 | 1.00 | RAF1 (0.45) | RAF1LCKPRKACAPRKACGPRKACB | |
| SCHEMBL6091752 | 0.82 | MEN1 (0.49) | RAF1LCKPRKACAPRKACGPRKACB | |
| SCHEMBL6091747 | 0.82 | MEN1 (0.49) | RAF1LCKPRKACAPRKACGPRKACB | |
| SCHEMBL6088767 | 0.74 | SIRT2 (0.40) | SIRT1SIRT2SIRT5 | |
| SCHEMBL6088769 | 0.74 | SIRT2 (0.40) | SIRT1SIRT2SIRT5 | |
| SCHEMBL6090181 | 0.73 | METAP1 (0.50) | SIRT2PIM1PIM2MEN1RGS12 | |
| SCHEMBL6090188 | 0.73 | METAP1 (0.50) | SIRT2PIM1PIM2MEN1RGS12 | |
| SCHEMBL6088690 | 0.71 | RAF1 (0.47) | RAF1LCKPRKACAPRKACGPRKACB | |
| SCHEMBL6088695 | 0.71 | RAF1 (0.47) | RAF1LCKPRKACAPRKACGPRKACB | |
| SCHEMBL6091530 | 0.70 | LRRK2 (0.36) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |