Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6090985 | 0.89 | CHEK1 (0.37) | CHEK1KDRABL1RETPDGFRB | |
| SCHEMBL6089341 | 0.80 | KDR (0.46) | CHEK1KDRABL1RETPDGFRB | |
| SCHEMBL6089071 | 0.80 | CHEK1 (0.36) | CHEK1KDR | |
| SCHEMBL6089888 | 0.78 | KDR (0.49) | CHEK1KDRABL1RETPDGFRB | |
| SCHEMBL6089892 | 0.78 | KDR (0.49) | CHEK1KDRABL1RETPDGFRB | |
| SCHEMBL6091983 | 0.77 | CHEK1 (0.47) | CHEK1KDRABL1RETPDGFRB | |
| SCHEMBL6091989 | 0.77 | CHEK1 (0.47) | CHEK1KDRABL1RETPDGFRB | |
| SCHEMBL6089250 | 0.77 | KDR (0.45) | CHEK1KDR | |
| SCHEMBL6090365 | 0.77 | KDR (0.66) | CHEK1KDR | |
| SCHEMBL6092361 | 0.77 | CHEK1 (0.45) | CHEK1KDRABL1RETPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |