Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 5/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.48 |
| ▸ | RET | P07949 | 3/20 | 0.48 |
| ▸ | FLT3 | P36888 | 3/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 5/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 7/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 6/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | FLT1 | P17948 | 2/20 | 0.36 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.36 |
| ▸ | STK3 | Q13188 | 2/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6092165 | 1.00 | FGFR1 (0.48) | FGFR1PDGFRBRETFLT3ALK | |
| SCHEMBL6089296 | 0.92 | PDGFRB (0.44) | FGFR1PDGFRBRETFLT3ALK | |
| SCHEMBL6089306 | 0.92 | PDGFRB (0.44) | FGFR1PDGFRBRETFLT3ALK | |
| SCHEMBL6092643 | 0.91 | PDGFRB (0.43) | FGFR1PDGFRBRETFLT3ALK | |
| SCHEMBL6092663 | 0.84 | KDR (0.56) | FGFR1PDGFRBRETFLT3ALK | |
| SCHEMBL6092657 | 0.84 | KDR (0.56) | FGFR1PDGFRBRETFLT3ALK | |
| SCHEMBL6088802 | 0.80 | ABL1 (0.54) | FGFR1PDGFRBRETFLT3ALK | |
| SCHEMBL6093136 | 0.79 | PDGFRB (0.45) | FGFR1PDGFRBRETFLT3ALK | |
| SCHEMBL6093126 | 0.79 | PDGFRB (0.45) | FGFR1PDGFRBRETFLT3ALK | |
| SCHEMBL6089154 | 0.79 | PDGFRB (0.45) | FGFR1PDGFRBRETFLT3ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |