Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.38 |
| ▸ | FLT3 | P36888 | 5/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 7/20 | 0.32 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.32 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.32 |
| ▸ | FLT4 | P35916 | 3/20 | 0.31 |
| ▸ | KIT | P10721 | 2/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6092769 | 1.00 | CHEK1 (0.40) | CHEK1PDGFRBFLT3FGFR1ALK | |
| SCHEMBL6088002 | 0.91 | ALK (0.43) | CHEK1PDGFRBFLT3FGFR1ALK | |
| SCHEMBL6087996 | 0.91 | ALK (0.43) | CHEK1PDGFRBFLT3FGFR1ALK | |
| SCHEMBL6091394 | 0.86 | ABL1 (0.54) | CHEK1PDGFRBFLT3FGFR1ALK | |
| SCHEMBL6091398 | 0.86 | ABL1 (0.54) | CHEK1PDGFRBFLT3FGFR1ALK | |
| SCHEMBL6099515 | 0.81 | PDGFRB (0.43) | CHEK1PDGFRBFLT3FGFR1ALK | |
| SCHEMBL6087837 | 0.81 | PDGFRB (0.43) | CHEK1PDGFRBFLT3FGFR1ALK | |
| SCHEMBL6087845 | 0.81 | PDGFRB (0.43) | CHEK1PDGFRBFLT3FGFR1ALK | |
| SCHEMBL6101967 | 0.81 | KDR (0.54) | CHEK1PDGFRBFLT3FGFR1ALK | |
| SCHEMBL6089734 | 0.80 | CHEK1 (0.48) | CHEK1PDGFRBFLT3FGFR1ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | claimed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | claimed |
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | disclosed |