Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 2/20 | 0.47 |
| ▸ | CCR5 | P51681 | 1/20 | 0.44 |
| ▸ | GOT1 | P17174 | 6/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.42 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6097059 | 0.81 | MAPK14 (0.57) | MAPK14GAAMAPTRECQLGFER | |
| SCHEMBL6096895 | 0.81 | ALDH1A1 (0.47) | GAAMAPTHCRTR2 | |
| SCHEMBL3210544 | 0.81 | MAPK14 (0.65) | MAPK14GAAMAPTRECQLGFER | |
| Hydrochloric Acid SCHEMBL27576776 | 0.81 | MAPK14 (0.56) | MAPK14GAAMAPTRECQLGFER | |
| SCHEMBL6096614 | 0.80 | MAPK14 (0.56) | MAPK14GAAMAPTRECQLGFER | |
| SCHEMBL6094636 | 0.79 | MAPK14 (0.60) | MAPK14GAAMAPTRECQLMGLL | |
| SCHEMBL6094630 | 0.79 | MAPK14 (0.52) | MAPK14GAAMAPTRECQLGFER | |
| SCHEMBL23244192 | 0.78 | MAPK14 (0.59) | MAPK14GAAMAPTRECQLGFER | |
| SCHEMBL29576070 | 0.78 | MAPK14 (0.59) | MAPK14GAAMAPTRECQLGFER | |
| SCHEMBL2216397 | 0.78 | MAPK14 (0.64) | MAPK14GAAMAPTRECQLGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7084143-B2 | N-(indolecarbonyl) piperazine derivatives | MERCK PATENT GMBH (DE) | 2006-08-01 | — | — | US | claimed |
| US-6838461-B1 | N-(indolcarbonyl-)piperazine derivatives | MERCK PATENT GMBH (DE) | 2005-01-04 | — | — | US | claimed |
| US-20050096330-A1 | N-(indolecarbonyl) piperazine derivatives | BOETTCHER HENNING (DE) | 2005-05-05 | — | — | US | disclosed |
| CN-1364157-A | N-(indolcarbonyl) piperazin derivatives | MERCK PATENT GMBH (DE) | 2002-08-14 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050096330-A1 | N-(indolecarbonyl) piperazine derivatives | HTR2A, HTR2B, HTR2C | MAPK14 4409/4885GAA 2544/4885MAPT 1280/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.