Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.55 |
| ▸ | HTR2C | P28335 | 2/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | HTR1D | P28221 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
| ▸ | HTR2B | P41595 | 1/20 | 0.55 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27554167 | 0.99 | HTR2A (0.54) | HTR2AHTR2CDRD4SLC6A2HTR1D | |
| SCHEMBL5280616 | 0.82 | HTR2A (0.67) | HTR2AHTR2CDRD4SLC6A2HTR1D | |
| SCHEMBL5280612 | 0.82 | HTR2A (0.51) | HTR2AHTR2CDRD4SLC6A2HTR1D | |
| SCHEMBL6095091 | 0.77 | HCRTR1 (0.45) | MAPTSLC6A7ALDH1A1HPGDTSHR | |
| SCHEMBL6094555 | 0.76 | HSP90AA1 (0.45) | MAPTSLC6A7ALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL27574060 | 0.76 | HCRTR1 (0.45) | MAPTSLC6A7ALDH1A1HPGDTSHR | |
| SCHEMBL6096357 | 0.76 | GFER (0.65) | MAPTGFERALDH1A1HTTLMNA | |
| SCHEMBL6097059 | 0.75 | MAPK14 (0.57) | MAPTSLC6A7GFERMGLLHTT | |
| Hydrochloric Acid SCHEMBL27576776 | 0.74 | MAPK14 (0.56) | MAPTSLC6A7GFERMGLLHTT | |
| SCHEMBL5280317 | 0.73 | HTR2A (0.84) | HTR2AHTR2CDRD4SLC6A2HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7084143-B2 | N-(indolecarbonyl) piperazine derivatives | MERCK PATENT GMBH (DE) | 2006-08-01 | — | — | US | claimed |
| US-6838461-B1 | N-(indolcarbonyl-)piperazine derivatives | MERCK PATENT GMBH (DE) | 2005-01-04 | — | — | US | claimed |
| CN-1319532-C | Use of N- (indolylcarbonyl) piperazine derivatives | MERCK PATENT GMBH (DE) | 2007-06-06 | — | — | CN | disclosed |
| US-20050096330-A1 | N-(indolecarbonyl) piperazine derivatives | BOETTCHER HENNING (DE) | 2005-05-05 | — | — | US | disclosed |
| CN-1589147-A | Use of N-(indolecarbonyl-)piperazine derivatives | MERCK PATENT GMBH (DE) | 2005-03-02 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050096330-A1 | N-(indolecarbonyl) piperazine derivatives | HTR2A, HTR2B, HTR2C | HTR2A 1/4885HTR2C 3/4885DRD4 122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.