Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 4/20 | 0.39 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6330018 | 0.84 | HSP90AA1 (0.47) | HSP90AA1GAAKDM4EMAPTALDH1A1 | |
| SCHEMBL6325057 | 0.83 | HSP90AA1 (0.42) | HSP90AA1GAAKDM4EMAPTALDH1A1 | |
| SCHEMBL6096013 | 0.82 | PARP1 (0.41) | HSP90AA1GAAKDM4EMAPTALDH1A1 | |
| SCHEMBL6096015 | 0.81 | HTR2A (0.41) | HSP90AA1GAAKDM4EMAPTALDH1A1 | |
| SCHEMBL6330373 | 0.77 | HSP90AA1 (0.46) | HSP90AA1GAAKDM4EMAPTALDH1A1 | |
| SCHEMBL6095091 | 0.77 | HCRTR1 (0.45) | GAAKDM4EMAPTALDH1A1SLC6A7 | |
| SCHEMBL6096836 | 0.76 | HTR2A (0.55) | GAAMAPTALDH1A1SLC6A7 | |
| SCHEMBL6093813 | 0.76 | HTR2A (0.43) | HSP90AA1GAAKDM4EMAPTALDH1A1 | |
| SCHEMBL6093812 | 0.76 | PARP1 (0.39) | HSP90AA1GAAKDM4EMAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL27574060 | 0.76 | HCRTR1 (0.45) | GAAKDM4EMAPTALDH1A1SLC6A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7084143-B2 | N-(indolecarbonyl) piperazine derivatives | MERCK PATENT GMBH (DE) | 2006-08-01 | — | — | US | claimed |
| US-6838461-B1 | N-(indolcarbonyl-)piperazine derivatives | MERCK PATENT GMBH (DE) | 2005-01-04 | — | — | US | claimed |
| US-20050096330-A1 | N-(indolecarbonyl) piperazine derivatives | BOETTCHER HENNING (DE) | 2005-05-05 | — | — | US | disclosed |
| CN-1364157-A | N-(indolcarbonyl) piperazin derivatives | MERCK PATENT GMBH (DE) | 2002-08-14 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050096330-A1 | N-(indolecarbonyl) piperazine derivatives | HTR2A, HTR2B, HTR2C | HSP90AA1 2073/4885GAA 2544/4885KDM4E 4026/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.