Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 9/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27574061 | 0.99 | GHSR (0.56) | GHSRMAPK14GAAMAPTRECQL | |
| SCHEMBL6094559 | 0.92 | MAPK14 (0.56) | GHSRMAPK14GAAMAPTRECQL | |
| SCHEMBL6095064 | 0.84 | GHSR (0.57) | GHSRMAPK14GAAMAPTRECQL | |
| Hydrochloric Acid SCHEMBL27574062 | 0.83 | GHSR (0.56) | GHSRMAPK14GAAMAPTRECQL | |
| SCHEMBL6098047 | 0.80 | GHSR (0.61) | GHSRMAPK14MAPTKDM4EALDH1A1 | |
| SCHEMBL5283296 | 0.79 | MAPK14 (0.59) | GHSRMAPK14MAPTKDM4EALDH1A1 | |
| SCHEMBL5283293 | 0.79 | GHSR (0.52) | GHSRMAPK14KDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL27579504 | 0.79 | GHSR (0.60) | GHSRMAPK14MAPTKDM4EALDH1A1 | |
| SCHEMBL17443852 | 0.77 | GHSR (0.75) | GHSRMAPK14MAPTKDM4EALDH1A1 | |
| SCHEMBL6097059 | 0.76 | MAPK14 (0.57) | MAPK14GAAMAPTRECQLSLC6A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7084143-B2 | N-(indolecarbonyl) piperazine derivatives | MERCK PATENT GMBH (DE) | 2006-08-01 | — | — | US | claimed |
| US-6838461-B1 | N-(indolcarbonyl-)piperazine derivatives | MERCK PATENT GMBH (DE) | 2005-01-04 | — | — | US | claimed |
| US-20050096330-A1 | N-(indolecarbonyl) piperazine derivatives | BOETTCHER HENNING (DE) | 2005-05-05 | — | — | US | disclosed |
| EP-1198453-A2 | N-(INDOLCARBONYL-)PIPERAZIN DERIVATIVES | MERCK PATENT GmbH (DE) | 2002-04-24 | — | — | EP | disclosed |
| WO-2001007435-A2 | N-(INDOLCARBONYL-)PIPERAZIN DERIVATIVES ALS 5-HT2A-RECEPTOR LIGANDS | MERCK PATENT GMBH (DE) | 2001-02-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050096330-A1 | N-(indolecarbonyl) piperazine derivatives | HTR2A, HTR2B, HTR2C | GHSR 65/4885MAPK14 4409/4885GAA 2544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.