Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 10/20 | 0.49 |
| ▸ | NOS1 | P29475 | 1/20 | 0.48 |
| ▸ | NOS2 | P35228 | 1/20 | 0.48 |
| ▸ | PNMT | P11086 | 1/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | CFD | P00746 | 1/20 | 0.41 |
| ▸ | LOX | P28300 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1770370 | 0.80 | TP53 (0.50) | MAOB | |
| SCHEMBL4121634 | 0.80 | MAOB (0.49) | MAOBNOS1NOS2PNMTENPP2 | |
| SCHEMBL12408537 | 0.80 | PRSS1 (0.51) | MAOBNOS1NOS2 | |
| SCHEMBL606214 | 0.80 | TP53 (0.60) | MAOBNOS1NOS2PNMTENPP2 | |
| SCHEMBL4949955 | 0.79 | ST14 (0.58) | MAOBNOS1NOS2PNMTENPP2 | |
| Hydrochloric Acid SCHEMBL25370652 | 0.78 | MAOB (0.50) | MAOBNOS1NOS2PNMTENPP2 | |
| Hydrochloric Acid SCHEMBL31173733 | 0.78 | MAOB (0.50) | MAOBNOS1NOS2PNMTENPP2 | |
| Hydrochloric Acid SCHEMBL4932873 | 0.78 | TP53 (0.58) | MAOBNOS1NOS2PNMTENPP2 | |
| SCHEMBL20553118 | 0.78 | KDM4E (0.48) | MAOBNOS1NOS2PNMTENPP2 | |
| SCHEMBL30207536 | 0.78 | MAOB (0.70) | MAOBNOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7078565-B2 | Benzamide derivatives as antagonists of orexin receptors | SMITHKLINE BEECHAM PLC (GB) | 2006-07-18 | — | — | US | disclosed |
| US-20050020584-A1 | Benzamide derivatives as antagonists of orexin receptors | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020584-A1 | Benzamide derivatives as antagonists of orexin receptors | HCRTR2, HCRTR1, OXTR | MAOB 236/4885NOS1 3054/4885NOS2 2343/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.