Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.56 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6099924 | 1.00 | KDM4E (0.64) | KDM4EHIF1ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL6097470 | 0.99 | KDM4E (0.65) | KDM4EHIF1ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL6102421 | 0.91 | KDM4E (0.64) | KDM4EHIF1ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL6099871 | 0.90 | KDM4E (0.80) | KDM4EHIF1ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL6098606 | 0.90 | KDM4E (0.62) | KDM4EHIF1ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL6100965 | 0.89 | KDM4E (0.56) | KDM4EHIF1ASMN1; SMN2MAPTALDH1A1 | |
| Ethane SCHEMBL6099926 | 0.89 | KDM4E (0.75) | KDM4EHIF1ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL6097646 | 0.89 | KDM4E (0.61) | KDM4EHIF1ASMN1; SMN2MAPTALDH1A1 | |
| Ethane SCHEMBL6097475 | 0.88 | KDM4E (0.77) | KDM4EHIF1ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL6099685 | 0.88 | KDM4E (0.59) | KDM4EHIF1ASMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7041664-B2 | 2-aminoquinolinecarboxamides: neurokinin receptor ligands | NEUROGEN CORPORATION (US) | 2006-05-09 | — | — | US | disclosed |