Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6099924 | 0.99 | KDM4E (0.64) | KDM4EHIF1AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6097763 | 0.99 | KDM4E (0.64) | KDM4EHIF1AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6102421 | 0.92 | KDM4E (0.64) | KDM4EHIF1AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6099871 | 0.91 | KDM4E (0.80) | KDM4EHIF1AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6098606 | 0.91 | KDM4E (0.62) | KDM4EHIF1AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6100965 | 0.90 | KDM4E (0.56) | KDM4EHIF1AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6097646 | 0.90 | KDM4E (0.61) | KDM4EHIF1AALDH1A1SMN1; SMN2MAPT | |
| Ethane SCHEMBL6097475 | 0.89 | KDM4E (0.77) | KDM4EHIF1AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6099685 | 0.89 | KDM4E (0.59) | KDM4EHIF1AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6101980 | 0.89 | KDM4E (0.55) | KDM4EHIF1AALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020156095-A1 | 2-aminoquinolinecarboxamides: neurokinin receptor ligands | NEUROGEN CORPORATION | 2002-10-24 | — | — | US | claimed |
| WO-2000064877-A1 | 2-AMINOQUINOLINECARBOXAMIDES: NEUROKININ RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 2000-11-02 | — | — | WO | claimed |
| US-7041664-B2 | 2-aminoquinolinecarboxamides: neurokinin receptor ligands | NEUROGEN CORPORATION (US) | 2006-05-09 | — | — | US | disclosed |
| US-6894044-B2 | 2-aminoquinolinecarboxamides: neurokinin receptor ligands | NEUROGEN CORPORATION (US) | 2005-05-17 | — | — | US | disclosed |
| US-20040229907-A1 | 2-Aminoquinolinecarboxamides: neurokinin receptor ligands | NEUROGEN CORPORATION, A CORPORATION OF THE STATE OF DELAWARE | 2004-11-18 | — | — | US | disclosed |
| US-20020156095-A1 | 2-aminoquinolinecarboxamides: neurokinin receptor ligands | NEUROGEN CORPORATION | 2002-10-24 | — | — | US | disclosed |
| US-6369053-B1 | CENTRAL NERVOUS SYSTEM AND PERIPHERAL DISEASES; ALSO USEFUL AS PROBES FOR THE LOCALIZATION OF CELL SURFACE RECEPTORS; NONPEPTIDE NK-3 RECEPTOR ANTAGONISTS | NEUROGEN CORPORATION | 2002-04-09 | — | — | US | disclosed |
| WO-2000064877-A1 | 2-AMINOQUINOLINECARBOXAMIDES: NEUROKININ RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 2000-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229907-A1 | 2-Aminoquinolinecarboxamides: neurokinin receptor ligands | OPRL1, OPRK1, KCNQ3 | KDM4E 3541/4885HIF1A 3360/4885ALDH1A1 2033/4885 |
| US-20020156095-A1 | 2-aminoquinolinecarboxamides: neurokinin receptor ligands | KCNQ3, OPRK1, KCNQ1 | KDM4E 2712/4885HIF1A 3061/4885ALDH1A1 2180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.