Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 5/20 | 0.72 |
| ▸ | PLG | P00747 | 4/20 | 0.72 |
| ▸ | F2 | P00734 | 3/20 | 0.72 |
| ▸ | PLAT | P00750 | 3/20 | 0.72 |
| ▸ | KLK8 | O60259 | 3/20 | 0.72 |
| ▸ | F10 | P00742 | 3/20 | 0.72 |
| ▸ | KLK4 | Q9Y5K2 | 3/20 | 0.72 |
| ▸ | KLK1 | P06870 | 3/20 | 0.51 |
| ▸ | KLK2 | P20151 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6842194 | 1.00 | PLAU (0.72) | PLAUPLGF2PLATKLK8 | |
| SCHEMBL17113986 | 0.85 | PLAU (0.54) | PLAUPLGF2PLATKLK8 | |
| SCHEMBL4295336 | 0.84 | PLAU (1.00) | PLAUPLGF2PLATKLK8 | |
| SCHEMBL4297455 | 0.84 | PLAU (1.00) | PLAUPLGF2PLATKLK8 | |
| SCHEMBL17113963 | 0.84 | KLK1 (0.55) | PLAUPLGF2PLATKLK8 | |
| Hydrochloric Acid SCHEMBL7390446 | 0.83 | PLAU (0.98) | PLAUPLGF2PLATKLK8 | |
| SCHEMBL4761286 | 0.81 | PLG (0.62) | PLAUPLGF2PLATKLK8 | |
| SCHEMBL1363819 | 0.80 | F2 (0.56) | PLAUPLGF2PLATKLK8 | |
| Trifluoroacetic Acid SCHEMBL17113939 | 0.79 | PLAU (0.53) | PLAUPLGF2PLATKLK8 | |
| Hydrochloric Acid SCHEMBL7422244 | 0.79 | F2 (0.55) | PLAUPLGF2PLATKLK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7109326-B2 | Halo-alkoxycarbonyl prodrugs | GENENTECH, INC. (US) | 2006-09-19 | — | — | US | disclosed |