Sugi Predict

Sugi Predict / Compounds / SCHEMBL6098036

SCHEMBL6098036

SCHEMBL6098036

Nc1nc[nH]c2nccc(=O)c1-2

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GDA Q9Y2T3 1/20 0.36
▸ DAPK3 O43293 2/20 0.35
▸ PRKD3 O94806 2/20 0.35
▸ MAP4K4 O95819 2/20 0.35
▸ CSF1R P07333 2/20 0.35
▸ RET P07949 2/20 0.35
▸ FGFR1 P11362 2/20 0.35
▸ FLT1 P17948 2/20 0.35
▸ LTK P29376 2/20 0.35
▸ KDR P35968 2/20 0.35
▸ CSNK1A1 P48729 2/20 0.35
▸ CDK7 P50613 2/20 0.35
▸ RPS6KA3 P51812 2/20 0.35
▸ CDK5 Q00535 2/20 0.35
▸ TYRO3 Q06418 2/20 0.35
▸ CLK4 Q9HAZ1 2/20 0.35
▸ ALK Q9UM73 2/20 0.35
▸ DYRK1B Q9Y463 2/20 0.35
▸ CHEK1 O14757 1/20 0.35
▸ GRK5 P34947 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ribose (Furanose) SCHEMBL6101236 0.79 PNP (0.38) —
SCHEMBL87556 0.72 GDA (0.36) GDACSNK1A1TYRO3DYRK1BLRRK2
Hydrochloric Acid SCHEMBL21683018 0.71 GDA (0.35) GDACSNK1A1TYRO3DYRK1BLRRK2
Hydrochloric Acid SCHEMBL29616692 0.71 GDA (0.35) GDACSNK1A1TYRO3DYRK1BLRRK2
SCHEMBL13822498 0.66 NISCH (0.40) CSNK1A1CDK5TYRO3DYRK1BKDM4E
SCHEMBL9437096 0.65 PI4KA (0.34) GDALRRK2
Toyocamycin Aglycone SCHEMBL7698540 0.62 CSNK1A1 (0.41) GDACSF1RFGFR1FLT1KDR
SCHEMBL5522173 0.62 GDA (0.32) GDA
SCHEMBL4455591 0.60 — —
SCHEMBL402483 0.60 PI4KA (0.45) GDALRRK2KDM4EGAAPARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2173352-B1 INHIBITORS OF AKT/PKB WITH ANTI-TUMOR ACTIVITY UNIV SOUTH FLORIDA (US) 2016-09-07 — — EP disclosed
US-7081449-B2 Pyrido[2,3-d]pyrimidine and pyrimido[4,5-d]pyrimidine nucleosides VALEANT RESEARCH & DEVELOPMENT (US) 2006-07-25 — — US disclosed
WO-2004080466-A1 CYTIDINE ANALOGS AND METHODS OF USE RIBAPHARM INC. (US) 2004-09-23 — — WO disclosed
EP-1303282-A4 PYRIDO[2,3-D]PYRIMIDINE AND PYRIMIDO[4,5-D]PYRIMIDINE NUCLEOSIDES RIBAPHARM INC (US) 2004-04-07 — — EP disclosed
US-20030144502-A1 Pyrido[2,3-d]pyrimidine and pyrimido[4,5-d]pyrimidine nucleosides MDRNA RESEARCH, INC. 2003-07-31 — — US disclosed
EP-1303282-A1 PYRIDO[2,3-D]PYRIMIDINE AND PYRIMIDO[4,5-D]PYRIMIDINE NUCLEOSIDES Ribapharm, Inc. (US) 2003-04-23 — — EP disclosed
WO-2002003997-A1 PYRIDO[2,3-D]PYRIMIDINE AND PYRIMIDO[4,5-D]PYRIMIDINE NUCLEOSIDES RIBAPHARM INC. (US) 2002-01-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030144502-A1 Pyrido[2,3-d]pyrimidine and pyrimido[4,5-d]pyrimidine nucleosides DPYD, TYMP, PNPO GDA 255/4885DAPK3 1755/4885PRKD3 471/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.