Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.75 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.75 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.75 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | RECQL | P46063 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2348949 | 0.88 | PDE4A (0.85) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL6556059 | 0.86 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL14407557 | 0.86 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL14363850 | 0.86 | KDM4E (0.60) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL26079023 | 0.85 | MEN1 (0.70) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL28206539 | 0.85 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL875834 | 0.84 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL3821434 | 0.83 | TSHR (0.59) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL15106441 | 0.83 | TSHR (0.54) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL7069119 | 0.82 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109384731-B | Method for preparing quinazolinone from enol | 南京理工大学 | 2021-10-08 | — | — | CN | disclosed |
| CN-109384731-A | A method of quinazolinone is prepared by enol | 南京理工大学 | 2019-02-26 | — | — | CN | disclosed |
| US-7053216-B2 | Modulators of Rho C activity | ICONIX PHARMACEUTICALS, INC. (US) | 2006-05-30 | — | — | US | disclosed |
| US-20030171387-A1 | Modulators of Rho C activity | ENTELOS HOLDING CORP. | 2003-09-11 | — | — | US | disclosed |
| WO-2003043961-A2 | MODULATORS OF RHO C ACTIVITY | ICONIX PHARMACEUTICALS, INC. (US) | 2003-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030171387-A1 | Modulators of Rho C activity | RHOC, ROCK1, CIT | PDE4A 950/4885PDE4B 1234/4885PDE4C 567/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.