Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 9/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 9/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 9/20 | 0.37 |
| ▸ | MAOA | P21397 | 7/20 | 0.37 |
| ▸ | MAOB | P27338 | 7/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8126438 | 0.89 | TSHR (0.42) | TLR8MEN1TSHRKMT2ASMN1; SMN2 | |
| SCHEMBL19475891 | 0.87 | CTNNB1 (0.41) | TLR8TLR7NUDT1TSHRKMT2A | |
| SCHEMBL15205345 | 0.87 | TLR7 (0.40) | TLR8TLR7NUDT1TSHRRAB9A | |
| SCHEMBL3666095 | 0.87 | TLR8 (0.41) | TLR8TLR7NUDT1RAB9AKDM4E | |
| SCHEMBL15205343 | 0.87 | TLR7 (0.40) | TLR8TLR7NUDT1TSHRRAB9A | |
| SCHEMBL5616314 | 0.86 | TLR8 (0.38) | TLR8TLR7NUDT1MEN1TSHR | |
| SCHEMBL29385735 | 0.85 | TLR7 (0.57) | TLR8TLR7NUDT1MEN1TSHR | |
| SCHEMBL4532094 | 0.85 | TLR7 (0.57) | TLR8TLR7NUDT1MEN1TSHR | |
| SCHEMBL5618202 | 0.84 | TLR8 (0.39) | TLR8TLR7NUDT1MEN1TSHR | |
| SCHEMBL31580844 | 0.83 | TLR8 (0.39) | TLR8TLR7NUDT1MEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7112677-B2 | 1H-imidazo dimers | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2006-09-26 | — | — | US | disclosed |
| EP-1542688-A2 | 1H-IMIDAZO DIMERS | 3M Innovative Properties Company (US) | 2005-06-22 | — | — | EP | disclosed |
| US-20050026947-A1 | 1H-imidazo dimers | 3M INNOVATIVE PROPERTIES COMPANY | 2005-02-03 | — | — | US | disclosed |
| US-6818650-B2 | 1H-IMIDAZO(4,5-C)- QUINOLINE OR -PYRIDINE DERIVATIVES; INDUCE BIOSYNTHESIS OF CYTOKINES; VIRAL DISEASES; ANTICARCINOGENIC AND ANTITUMOR AGENTS; IMMUNOMODULATORS | 3M INNOVATIVE PROPERTIES COMPANY | 2004-11-16 | — | — | US | disclosed |
| US-20040132766-A1 | 1H-imidazo dimers | 3M INNOVATIVE PROPERTIES COMPANY | 2004-07-08 | — | — | US | disclosed |
| WO-2004028539-A2 | 1H-IMIDAZO DIMERS | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2004-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026947-A1 | 1H-imidazo dimers | IL2, EIF2AK2, IRF3 | TLR8 176/4885TLR7 173/4885NUDT1 1332/4885 |
| US-20040132766-A1 | 1H-imidazo dimers | IL2, EIF2AK2, IRF3 | TLR8 176/4885TLR7 173/4885NUDT1 1332/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.