Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 10/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1960054 | 0.88 | TLR7 (0.42) | TLR8KDM4ETLR7ALDH1A1 | |
| SCHEMBL6098569 | 0.87 | TLR8 (0.42) | TLR8KDM4EMAPTTLR7NUDT1 | |
| SCHEMBL19475891 | 0.85 | CTNNB1 (0.41) | TLR8KDM4ETLR7NUDT1ALDH1A1 | |
| SCHEMBL15205345 | 0.85 | TLR7 (0.40) | TLR8KDM4EMAPTTLR7NUDT1 | |
| SCHEMBL15205343 | 0.85 | TLR7 (0.40) | TLR8KDM4EMAPTTLR7NUDT1 | |
| SCHEMBL5616314 | 0.84 | TLR8 (0.38) | TLR8KDM4EMAPTTLR7NUDT1 | |
| SCHEMBL5346497 | 0.81 | TLR7 (0.48) | TLR8TLR7 | |
| SCHEMBL2892852 | 0.81 | TLR7 (0.40) | TLR8TLR7NUDT1 | |
| SCHEMBL8126438 | 0.81 | TSHR (0.42) | TLR8KDM4EMAPTALDH1A1USP2 | |
| SCHEMBL5618202 | 0.80 | TLR8 (0.39) | TLR8KDM4EMAPTTLR7NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155743-B1 | IMIDAZOQUINOLINES WITH IMMUNO-MODULATING PROPERTIES | ASTRAZENECA AB (SE) | 2012-08-29 | — | — | EP | disclosed |
| EP-2155743-A1 | IMIDAZOQUINOLINES WITH IMMUNO-MODULATING PROPERTIES | AstraZeneca AB (SE) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008135791-A1 | IMIDAZOQUINOLINES WITH IMMUNO-MODULATING PROPERTIES | ASTRAZENECA AB (SE) | 2008-11-13 | — | — | WO | disclosed |