Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 3/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.53 |
| ▸ | TACR3 | P29371 | 1/20 | 0.52 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | ELANE | P08246 | 2/20 | 0.48 |
| ▸ | HPGDS | O60760 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MDM4 | O15151 | 1/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6402692 | 0.94 | ALOX5 (0.54) | CDK2HDAC1HDAC6TACR3LNPEP | |
| SCHEMBL6402696 | 0.94 | ALOX5 (0.54) | CDK2HDAC1HDAC6TACR3LNPEP | |
| SCHEMBL4829792 | 0.94 | CDK2 (0.59) | CDK2HDAC1HDAC6TACR3KDR | |
| SCHEMBL4829786 | 0.94 | CDK2 (0.59) | CDK2HDAC1HDAC6TACR3KDR | |
| SCHEMBL5926753 | 0.94 | CDK2 (0.53) | CDK2HDAC1HDAC6TACR3LNPEP | |
| SCHEMBL6099076 | 0.89 | CDK2 (0.59) | CDK2HDAC1HDAC6TACR3KDR | |
| SCHEMBL5926311 | 0.89 | CDK2 (0.57) | CDK2HDAC1HDAC6TACR3KDR | |
| SCHEMBL4831777 | 0.89 | CDK2 (0.55) | CDK2HDAC1HDAC6TACR3KDR | |
| SCHEMBL4831785 | 0.89 | CDK2 (0.55) | CDK2HDAC1HDAC6TACR3KDR | |
| SCHEMBL5926522 | 0.87 | CDK2 (0.61) | CDK2HDAC1HDAC6TACR3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7459472-B2 | Aryl and heteroaryl compounds, compositions, and methods of use | TRANSTECH PHARMA, INC. (US) | 2008-12-02 | — | — | US | disclosed |
| US-7459472-B2 | Aryl and heteroaryl compounds, compositions, and methods of use | TRANSTECH PHARMA, INC. (US) | 2008-12-02 | — | — | US | disclosed |
| US-7122580-B2 | Aryl and heteroaryl compounds and methods to modulate coagulation | TRANSTECH PHARMA, INC. (US) | 2006-10-17 | — | — | US | disclosed |
| WO-2004014844-A2 | ARYL AND HETEROARYL COMPOUNDS AND METHODS TO MODULATE COAGULATION | TRANSTECH PHARMA, INC. (US) | 2004-02-19 | — | — | WO | disclosed |