Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 3/20 | 0.67 |
| ▸ | EGFR | P00533 | 12/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.59 |
| ▸ | KDM1A | O60341 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 5/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.53 |
| ▸ | FLT1 | P17948 | 1/20 | 0.53 |
| ▸ | FBP1 | P09467 | 1/20 | 0.53 |
| ▸ | CLK1 | P49759 | 1/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | GAK | O14976 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4371491 | 0.91 | RET (0.74) | RETEGFRERBB2KDM1AKDR | |
| SCHEMBL4380715 | 0.88 | RET (0.70) | RETEGFRERBB2KDM1AKDR | |
| SCHEMBL8561433 | 0.87 | RET (0.83) | RETEGFRERBB2KDRFLT1 | |
| SCHEMBL6101316 | 0.86 | RET (0.62) | RETEGFRERBB2KDM1AKDR | |
| Hydrochloric Acid SCHEMBL8904802 | 0.86 | RET (0.81) | RETEGFRERBB2KDRFLT1 | |
| SCHEMBL6098674 | 0.84 | RET (0.61) | RETEGFRERBB2KDM1AKDR | |
| Hydrochloric Acid SCHEMBL7846769 | 0.83 | RET (0.66) | RETEGFRERBB2KDRFGFR1 | |
| SCHEMBL6031335 | 0.83 | EGFR (0.58) | RETEGFRKDM1AKDRFGFR1 | |
| SCHEMBL6100567 | 0.83 | RET (0.58) | RETEGFRERBB2KDRFGFR1 | |
| SCHEMBL6031255 | 0.82 | RET (0.67) | RETEGFRERBB2KDRCLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492560-B2 | Quinazoline derivatives as angiogenesis inhibitors | ASTRAZENECA AB (SE) | 2013-07-23 | — | — | US | disclosed |
| US-7074800-B1 | Quinazoline derivatives as angiogenesis inhibitors | ASTRAZENECA AB (SE) | 2006-07-11 | — | — | US | disclosed |
| EP-1154774-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | AstraZeneca AB (SE) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000047212-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ASTRAZENECA AB (SE) | 2000-08-17 | — | — | WO | disclosed |