Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 10/20 | 0.78 |
| ▸ | HTR1B | P28222 | 10/20 | 0.78 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6099855 | 0.92 | HTR1D (0.64) | HTR1DHTR1BHTR1AMAPTLMNA | |
| SCHEMBL6101079 | 0.91 | HTR1B (0.72) | HTR1DHTR1BHTR1AMAPT | |
| SCHEMBL6101604 | 0.89 | HTR1D (0.61) | HTR1DHTR1BHTR1AMAPTLMNA | |
| SCHEMBL6101776 | 0.89 | HTR1D (0.61) | HTR1DHTR1BHTR1ALMNATP53 | |
| SCHEMBL6101995 | 0.87 | HTR1D (0.84) | HTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL6100097 | 0.83 | HTR1D (0.76) | HTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL6168850 | 0.81 | HTR1D (0.71) | HTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL6102593 | 0.81 | HTR1D (0.71) | HTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL6604795 | 0.81 | HTR1D (0.77) | HTR1DHTR1BHTR1AMAPTHTR2A | |
| SCHEMBL6603417 | 0.81 | HTR1D (1.00) | HTR1DHTR1BHTR1AMAPTHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7109201-B2 | Piperazine derivatives, their preparation and uses in therapy | SMITHKLINE BEECHAM PLC (GB) | 2006-09-19 | — | — | US | claimed |