Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 8/20 | 0.61 |
| ▸ | HTR1B | P28222 | 8/20 | 0.61 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6099855 | 0.93 | HTR1D (0.64) | HTR1DHTR1BTP53MAPTTHRB | |
| SCHEMBL6101776 | 0.91 | HTR1D (0.61) | HTR1DHTR1BTP53THRBLMNA | |
| SCHEMBL6100482 | 0.89 | HTR1D (0.78) | HTR1DHTR1BTP53MAPTTHRB | |
| SCHEMBL6101983 | 0.81 | HTR1D (0.41) | HTR1DHTR1BMAPT | |
| SCHEMBL6101079 | 0.80 | HTR1B (0.72) | HTR1DHTR1BMAPTHTR1A | |
| SCHEMBL5421774 | 0.78 | HTR1D (0.57) | HTR1DHTR1BTP53MAPTTHRB | |
| SCHEMBL6102410 | 0.77 | HTR1D (0.66) | HTR1DHTR1BTP53MAPTLMNA | |
| SCHEMBL6101995 | 0.76 | HTR1D (0.84) | HTR1DHTR1BHTR1A | |
| SCHEMBL6102088 | 0.76 | HTR1D (0.42) | HTR1DHTR1BMAPT | |
| SCHEMBL6101456 | 0.74 | HTR1D (0.41) | HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7109201-B2 | Piperazine derivatives, their preparation and uses in therapy | SMITHKLINE BEECHAM PLC (GB) | 2006-09-19 | — | — | US | claimed |