Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | HCRTR1 | O43613 | 14/20 | 0.53 |
| ▸ | HCRTR2 | O43614 | 9/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7869499 | 1.00 | CYP3A4 (0.54) | CYP3A4HCRTR1HCRTR2 | |
| SCHEMBL608587 | 0.90 | HCRTR1 (0.65) | HCRTR1HCRTR2 | |
| SCHEMBL611279 | 0.90 | CYP3A4 (0.52) | CYP3A4HCRTR1HCRTR2 | |
| SCHEMBL610803 | 0.87 | HCRTR1 (0.50) | HCRTR1HCRTR2 | |
| SCHEMBL7868917 | 0.87 | HCRTR2 (0.52) | CYP3A4HCRTR1HCRTR2 | |
| SCHEMBL609531 | 0.87 | HCRTR2 (0.52) | CYP3A4HCRTR1HCRTR2 | |
| SCHEMBL7871769 | 0.87 | HCRTR1 (0.49) | HCRTR1HCRTR2 | |
| SCHEMBL607949 | 0.87 | HCRTR1 (0.49) | HCRTR1HCRTR2 | |
| SCHEMBL608175 | 0.87 | HCRTR1 (0.54) | HCRTR1HCRTR2 | |
| SCHEMBL609008 | 0.86 | HCRTR1 (0.42) | CYP3A4HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120040991-A1 | 3-AZABICYCLO [4.1.0] HEPTANES USED AS OREXIN ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2012-02-16 | — | — | US | claimed |
| US-20120040991-A1 | 3-AZABICYCLO [4.1.0] HEPTANES USED AS OREXIN ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2012-02-16 | — | — | US | disclosed |
| US-20120040991-A1 | 3-AZABICYCLO [4.1.0] HEPTANES USED AS OREXIN ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040991-A1 | 3-AZABICYCLO [4.1.0] HEPTANES USED AS OREXIN ANTAGONISTS | HCRTR2, HCRTR1, NPY2R | CYP3A4 862/4885HCRTR1 2/4885HCRTR2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.