Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.44 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6104410 | 1.00 | GBA1 (0.48) | GBA1ALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL6104418 | 1.00 | GBA1 (0.48) | GBA1ALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL6102412 | 1.00 | GBA1 (0.48) | GBA1ALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL6102402 | 1.00 | GBA1 (0.48) | GBA1ALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL4476414 | 0.89 | ALDH1A1 (0.47) | GBA1ALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL5723982 | 0.89 | ALDH1A1 (0.47) | GBA1ALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL5723978 | 0.89 | ALDH1A1 (0.47) | GBA1ALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL5724018 | 0.86 | SMN1; SMN2 (0.51) | GBA1ALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL6400164 | 0.85 | ALDH1A1 (0.46) | ALDH1A1LMNASMN1; SMN2MAPTRAB9A | |
| SCHEMBL5724224 | 0.85 | ALDH1A1 (0.49) | ALDH1A1LMNASMN1; SMN2MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060004084-A1 | (3Z)-3-(2,3-dihydro-1H-inden-1-ylidene)-1,3-dihydro-2H-indol-2-ones as kinase inhibitors | ALLERGAN, INC. | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004084-A1 | (3Z)-3-(2,3-dihydro-1H-inden-1-ylidene)-1,3-dihydro-2H-indol-2-ones as kinase inhibitors | CDK2, ERBB2, MAP3K3 | GBA1 4722/4885ALDH1A1 1528/4885LMNA 3833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.