SCHEMBL6103449

SCHEMBL6103449

Cn1cnc(C(=O)N(Cc2ccc(Cl)c(Cl)c2)CC2C3CNCC32)c1

nearest known ligand 0.84

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SLC6A9 P48067 19/20 0.84
KCNH2 Q12809 13/20 0.84
SLC6A5 Q9Y345 6/20 0.51
CYP3A4 P08684 3/20 0.51
CYP2D6 P10635 2/20 0.42
CYP1A2 P05177 1/20 0.40
CYP2C9 P11712 1/20 0.40
SLC6A2 P23975 1/20 0.40
SLC6A4 P31645 1/20 0.40
CYP2C19 P33261 1/20 0.40
SLC6A3 Q01959 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6102680 0.91 SLC6A9 (0.98) SLC6A9KCNH2SLC6A5CYP3A4CYP2D6
SCHEMBL710028 0.90 SLC6A9 (0.84) SLC6A9KCNH2SLC6A5CYP3A4CYP2D6
SCHEMBL6106257 0.88 SLC6A9 (0.82) SLC6A9KCNH2SLC6A5CYP3A4CYP2D6
Hydrochloric Acid SCHEMBL6105309 0.88 SLC6A9 (0.98) SLC6A9KCNH2SLC6A5CYP3A4CYP2D6
SCHEMBL710411 0.87 SLC6A9 (0.80) SLC6A9KCNH2SLC6A5CYP3A4CYP2D6
SCHEMBL6105648 0.85 SLC6A9 (0.74) SLC6A9KCNH2SLC6A5CYP3A4CYP2D6
SCHEMBL6102624 0.84 SLC6A9 (0.70) SLC6A9KCNH2SLC6A5CYP3A4CYP2D6
SCHEMBL6103618 0.84 SLC6A9 (0.80) SLC6A9KCNH2SLC6A5CYP3A4CYP2D6
SCHEMBL709997 0.84 SLC6A9 (0.85) SLC6A9KCNH2SLC6A5CYP3A4CYP2D6
SCHEMBL6103595 0.84 SLC6A9 (0.78) SLC6A9KCNH2SLC6A5CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060229455-A1 Bicyclic [3.1.0.] heteroaryl amides as type 1 glycine transport inhibitors PFIZER INC. 2006-10-12 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060229455-A1 Bicyclic [3.1.0.] heteroaryl amides as type 1 glycine transport inhibitors SLC1A2, SLC1A1, GLRA1 SLC6A9 11/4885KCNH2 733/4885SLC6A5 6/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.