Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 2/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 8/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.40 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.40 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | TTK | P33981 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6107637 | 0.93 | MAPK10 (0.43) | MAPK14MAPK10CDK4MAPK8MAPK9 | |
| SCHEMBL6104157 | 0.87 | CDK4 (0.43) | MAPK14MAPK10CDK4MAPK8MAPK9 | |
| SCHEMBL6104241 | 0.87 | CDK4 (0.43) | MAPK10CDK4MAPK8MAPK9AURKA | |
| SCHEMBL6105760 | 0.87 | MAPK10 (0.49) | MAPK14MAPK10CDK4MAPK8MAPK9 | |
| SCHEMBL6105435 | 0.87 | MAPK10 (0.52) | MAPK14MAPK10CDK4MAPK8MAPK9 | |
| SCHEMBL6106982 | 0.85 | TP53 (0.46) | MAPK10CDK4MAPK8MAPK9KDR | |
| SCHEMBL6107098 | 0.85 | CDK4 (0.50) | MAPK14MAPK10CDK4MAPK8KDR | |
| SCHEMBL6106438 | 0.85 | ADORA1 (0.48) | MAPK10CDK4MAPK8MAPK9DGAT1 | |
| SCHEMBL6106593 | 0.85 | TP53 (0.46) | MAPK14MAPK10CDK4MAPK8MAPK9 | |
| SCHEMBL6105643 | 0.85 | CDK4 (0.43) | MAPK14MAPK10CDK4MAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7153855-B2 | Pyrazolopyridinyl pyrimidine therapeutic compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2006-12-26 | — | — | US | claimed |
| US-20050049260-A1 | Therapeutic compounds | SMITHKLINE BEECHAM CORPORATION | 2005-03-03 | — | — | US | claimed |
| US-7153855-B2 | Pyrazolopyridinyl pyrimidine therapeutic compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2006-12-26 | — | — | US | disclosed |
| US-20050049260-A1 | Therapeutic compounds | SMITHKLINE BEECHAM CORPORATION | 2005-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050049260-A1 | Therapeutic compounds | ABCB1, PCSK9, ABCB11 | MAPK14 4328/4885MAPK10 2227/4885CDK4 2304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.